GHK-Cu

What is GHK-Cu?

GHK-Cu is a copper-binding tripeptide (glycyl-L-histidyl-L-lysine + Cu²⁺), first isolated from human plasma in 1973. The copper coordination gives the compound its deep blue color in solution — a normal visual signature, not a sign of degradation.

Research mechanism

Published research has examined the following mechanisms:

• Copper transport — GHK delivers Cu(II) to enzyme systems including lysyl oxidase and SOD.
• ECM modulation — effects on collagen and glycosaminoglycan synthesis in fibroblast cultures.
• Gene expression — genome-wide microarray studies show modulation of thousands of human genes.
• Wound healing — animal research in skin repair and antioxidant defense models.

Note: All mechanism data is from published research. Not FDA-approved for human use.

Physical properties & handling

Reconstitute 100 mg with 2.0 mL bacteriostatic water (50 mg/mL). Deep blue color is expected. Refrigerate 2–8°C; use within 28 days. Protect from prolonged light.

Quality specifications (Broceutical GHK-Cu)

• Purity: 99.2% typical (HPLC verified)
• Copper content: ICP-MS verified
• Endotoxin: <1 EU/mg (LAL)
• Form: Lyophilized blue-green powder

Published research references

• Pickart L, Margolina A. "Regenerative and Protective Actions of the GHK-Cu Peptide." Int J Mol Sci. 2018;19(7):1987. PubMed PMID: 29986520
• Pickart L, et al. "GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration." Biomed Res Int. 2015;2015:648108. PubMed PMID: 26236730
• PubMed literature search https://pubmed.ncbi.nlm.nih.gov/?term=GHK-Cu

Broceutical does not endorse or make claims from the above research.