Cognitive class · ACTH(4-7) analog
Semax
ACTH(4-7) PGP · Met-Glu-His-Phe-Pro-Gly-Pro (7 aa)
Quick facts
Formula
C37H51N9O10S
Weight
813.93 g/mol
Class
Met-Glu-His-Phe-Pro-Gly-Pro (7 aa)
What is Semax?
Semax is a synthetic heptapeptide derived from residues 4-7 of ACTH, extended with Pro-Gly-Pro. Retains neurotropic effects without engaging the melanocortin/cortisol system.
Research mechanism
Published research has examined the following mechanisms:
- BDNF expression — effects in hippocampal and cortical tissue in animal models.
- NGF-related pathways — interaction with nerve growth factor signaling.
- Enkephalin degradation modulation.
- Ischemic protection — substantial research in cerebral ischemia models.
Note: All mechanism data is from published research. Not FDA-approved for human use.
Physical properties & handling
Reconstitute 5 mg with 1.0 mL bacteriostatic water. Very slight yellow tint is normal. Refrigerate; use within 28 days.
Quality specifications (Broceutical Semax)
- Purity: 99.3% typical
- Identity: LC-MS/MS confirmed
- Endotoxin: <1 EU/mg
- Form: Lyophilized powder
Published research references
- Kaplan AY, Kochetova AG. "Neurotropic action of Semax: results of years of research." Zh Vyssh Nerv Deiat Im I P Pavlova. 2011;61(5):527-46. PubMed PMID: 22165155
- PubMed literature search https://pubmed.ncbi.nlm.nih.gov/?term=semax
Broceutical does not endorse or make claims from the above research.
Research Use Only
Semax supplied by Broceutical is a research chemical for in-vitro laboratory research only. Not FDA-approved for human or veterinary use.