TB-500

What is TB-500?

TB-500 is a synthetic heptapeptide fragment corresponding to the active region of Thymosin Beta-4 (Tβ4), a 43-amino-acid actin-sequestering protein abundant in mammalian tissues. It contains the LKKTETQ actin-binding motif that drives research interest.

Research mechanism

Published research has examined the following mechanisms:

• G-actin sequestration — the LKKTETQ region binds monomeric G-actin, modulating cytoskeletal dynamics.
• Cell migration — studies have examined effects on endothelial cell and stem cell migration in wound-healing models.
• Angiogenesis — research on vascular tube formation and capillary sprouting in animal models.
• Inflammation modulation — some literature explores anti-inflammatory endpoints in tissue injury models.

Note: All mechanism data is from published research. Not FDA-approved for human use.

Physical properties & handling

Reconstitute a 5 mg vial with 1.0 mL bacteriostatic water (5 mg/mL). May require slightly longer dissolution — continue gentle swirling until clear. Refrigerate; use within 28 days.

Quality specifications (Broceutical TB-500)

• Purity: 99.4% typical (HPLC verified)
• Identity: LC-MS/MS confirmed
• Endotoxin: <1 EU/mg (LAL)
• Form: Lyophilized powder

Published research references

• Goldstein AL, et al. "Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues." Trends Mol Med. 2005;11(9):421-9. PubMed PMID: 16099719
• Crockford D, et al. "Thymosin beta 4: structure, function, and biological properties." Ann NY Acad Sci. 2010;1194:179-89. PubMed PMID: 20536467
• PubMed literature search https://pubmed.ncbi.nlm.nih.gov/?term=Thymosin+beta+4

Broceutical does not endorse or make claims from the above research.